What is the comparator of choice in pragmatic trials? And to what extent should treatment-related study procedures resemble routine clinical practice?
A series of eight papers has been published in the Journal of Clinical Epidemiology.
Introduction: Pragmatic trials and Real World Evidence
Selection and inclusion of usual care sites
Participant eligibility, recruitment and retention
Challenges of informed consent
Questions, comparators and treatment strategies
Outcome selection and measurement
Monitoring safety and trial conduct
Read more on Questions, comparators and treatment strategies in our JCE paper series, which discusses the choice of comparators in pragmatic trials.
For a summary, please click here.
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