The sites studied in a trial may influence the observed treatment effect and generalisability of the study results to the target population.
A series of eight papers has been published in the Journal of Clinical Epidemiology.
Introduction: Pragmatic trials and Real World Evidence
Selection and inclusion of usual care sites
Participant eligibility, recruitment and retention
Challenges of informed consent
Questions, comparators and treatment strategies
Outcome selection and measurement
Monitoring safety and trial conduct
Read more on the selection and inclusion of usual care sites in our JCE paper series, which discusses the pragmatic design choices related to site selection.
For a summary, please click here.
Read more on the specific challenges of site recruitment strategies in pragmatic trials, and the different recruitment strategies options available.
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