How to balance between including a representative population and the feasibility of running the trial?
A series of eight papers has been published in the Journal of Clinical Epidemiology.
Introduction: Pragmatic trials and Real World Evidence
Selection and inclusion of usual care sites
Participant eligibility, recruitment and retention
Challenges of informed consent
Questions, comparators and treatment strategies
Outcome selection and measurement
Monitoring safety and trial conduct
Read more on participant eligibility, recruitment and retention in our JCE paper series, which discusses the pragmatic design choices related to participants.
For a summary, please click here.
Read more on the specific challenges of participant recruitment strategies in pragmatic trials, and the different recruitment strategies options available.
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Read more on challenges of informed consent in our JCE paper series, which discusses the pragmatic design choices related to informed consent.