PragMagic

Pragmatic Trial resources

Decision support tool PragMagic

RESOURCES

The information on this page is centred around the topic of pragmatic trials. It can serve several purposes, be it to aid in the design of more pragmatic trials, to evaluate existing pragmatic trials or to be used as an educational resource for pragmatic trials. To read more on pragmatic trials and how they relate to more explanatory trials, please read our paper on pragmatic trials and real world evidence.

As this website is still under construction, we will be adding new publications and sources of information.

PRAGMATIC TRIALS

A pragmatic trial aims to capture the true effect of a treatment strategy in the real world. Selecting the setting, study population, mode of intervention, comparator and outcome are crucial in designing pragmatic trials. Read more...

RELEVANT INITIATIVES & TOOLS

KEY PUBLICATIONS

STAKEHOLDER PERSPECTIVES

Will follow shortly

SITE

The sites studied in a trial may influence the observed treatment effect and generalisability of the study results to the target population. Read more...

COMPARATOR

What is the comparator of choice in pragmatic trials? And to what extent should treatment-related study procedures resemble routine clinical practice? Read more...

SAFETY & QUALITY

Obligations for monitoring of safety and trial conduct may affect routine clinical practice care. Read more on RBM and timely capture of data on serious adverse events. Read more...

PARTICIPANT

How to balance between including a representative population and the feasibility of running the trial? Read more...

OUTCOME

Outcomes in pragmatic trials should be relevant for patients, clinicians and decision-making. Read more...

DATA

Data collection in pragmatic trials, should we use eCRF or existing routine systems (e.g. EHR)? Read more...