Pragmatic Trial resources


PragMagic has been updated and renamed to the GetReal Trial Tool. Please visit to use the tool. Your PragMagic account details remain valid in the new tool and your project data is still available. This website will be taken offline soon.

Pragmatic Trials

The information on this website is centred around the topic of pragmatic trials. It can serve several purposes, be it to aid in the design of more pragmatic trials, to evaluate existing pragmatic trials or to be used as an educational resource for pragmatic trials.

Pragmatic trials aim to capture the true effect of a treatment strategy in the real world. As such, they provide a great opportunity to generate real-world evidence in the early stages of drug development.

However, pragmatic trials are still in their early days and experience with designing and executing these trials is limited. Therefore, the PragMagic Tool, a decision support tool and educational tool for pragmatic trial design and protocol evaluation, has been developed. Also, additional resources on specific challenges for pragmatic trials have been bundled on this website.

Latest News

We are proud to anounce that a series of eight papers on pragmatic trials has been published in the Journal of Clinical Epidemiology.  In this series we integrate the theoretical design options with the practice of conducting pragmatic trials. For more information, please click here.

Posted on July 31st, 2017 09:57

The PragMagic tool is online! On June 8th, The PragMagic Launch: an innovative tool to assist pragmatic trial design webinar took place, and discussed pragmatic trials and the design and usability of the PragMagic Tool. The webinar can be viewed here.

Posted on June 8th, 2017 17:00

PragMagic Tool






The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no [115546], resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013) and EFPIA companies in kind contribution.